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KMID : 0359819930220090947
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 9 p.947 ~ p.952
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Experimental Study of the Effect of Nimodipine on CSF Formation
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송준혁
박윤관/정홍섭/서중근/이훈갑/이기찬/주정화
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Abstract
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The author has performed an experimental study in order to investigate the effect of nimodipine on the production of CSF in 12 cats. The cats were divided into 2 groups, one for nimodipine intravenous infusion and the other for its vehicle
infusion
group. Using ventriculo-cisternal perfusion method, nimodipine and its vehicle were examined for their effects on CSF formation rate respectively. Baseline CSF formation rate was 22.5±2.9μl/min (S. E.) and it gradually reduced to
17.0±3.4μl/min
(S.
e.) after final infusion of nimodipine at 60μg/kg/min.
Vehicle infusion revealed no significant change in CSF formation rate. Although the nimodipine insuion revealed declining tendency in CSF formation rate along with increment of nimodipine concentration. it was not statistically different from
that
of
vehicle infusion group. Systolic blood pressure was significantly reduced after nimodipine infusion (133±31.8mmHg at baseline, 93.9±19.1 mmHg at the end of the experiemtn) on oneway ANOVA test and it was significantly difierent from that in
vehicle
infusion group (p<0.01).
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KEYWORD
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